01 - In a small bowl, combine the kosher salt, black pepper, smoked paprika, garlic powder, and onion powder. Stir until evenly blended.
02 - Pat the tilapia fillets thoroughly dry with paper towels. Sprinkle both sides of each fillet evenly with the seasoning blend.
03 - If using, lightly dredge each seasoned fillet in cornmeal or gluten-free flour, shaking off any excess for a thin, even crust.
04 - Heat the olive oil or butter in a large nonstick skillet over medium-high heat until the oil shimmers or the butter begins to foam.
05 - Carefully place the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3 to 4 minutes on the first side until golden brown and the fish releases easily from the pan. Flip gently using a fish spatula and cook for another 2 to 3 minutes until the flesh is opaque and flakes easily with a fork.
06 - Transfer the fillets to warm plates and serve immediately with fresh lemon wedges alongside steamed vegetables, a crisp salad, or rice.